Twenty-one RH-787-intoxicated patients were studied prospectively, and the results were as follows.
1. Twenty-one cases intoxicated by roclenticide RH-787(5 to 40 gm of 2 per cent RH-787) included 6 cases of male and 15 cases of female ranging 18 to 51 (years of age.
2. Clinical manifestations were areflexia (61.9%), abdominal discomfort (57.0%), tingling sensation, numbness, drowsy mental state, headache, general weakness, dizziness, urinary retention, burning foot, thirst, polyuria, tachycardia, bradycardia, blurred vision, insomnia, and convulsion.
3. Fasting blood glucose levels were ranged 65 to 791 mg/100 ml(mean; 222.Omg/IOOml), 71.4 per cent of cases showed increased values of fasting blood glucose, and abnormal glucose tolerances were found in 4 of 6 cases of normoglycemia at fasting state. 90. 1 per cent of RH-787-intoxicated cases had high levels of fasting blood glucose and abnormal glucose tolerances.
4. Three cases had high values of serum amylase and lipase, and four cases had high levels of BUN, NPN, and creatinine, however, they were normalized following 1 y control of blood glucose. Serum electrolyte(Na, Cl, K, and Ca) levels were within normal limit except one case of hyperpotassemia which was normalized after control of blood glucose.
5. Cerebrospinal fluid examination showed increased glucose (mean; 181. 3 mg/ 100 ml) and protein (mean; 82.7 mg 1100 ml), the former were decreased and the latter were variable in changes by blood glucose control. But pressure and cell count showed within normal limit.
6. Abnormal electrocardiograms were seen in 60 per cent of cases including sinus bradycardia, tachycardia, left ventricular hypertrophy, premature atrial contraction, myocardial ischemia, prolongation of Q-T interval, and clockwise rotation.
7. Patients were treated with fluids and electrolytes, nicotinamide (600 to 1, 200mg per day), and insulin (8 to 84. units per day). Marked hyperglycemia could not. be altered by administration of ni totinamide. Seventeen cases(81. 0%) were improved.
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